Toxic effects of red mercuric iodide on kidney and liver of rabbits were studied histologically regarding to the dose and time after single oral administration of the drug.
The findings observed are as follows:
1. Cloudy swelling and coagukative necrotic changes in the linging epithelium of proximal convoluted tubules of kidney were observed 6 and 3 hours after administration in small (10mg/kg of body weight) and large dose (100mg of body weight) groups, respectively. These changes were aggravated in proportion to exposed time to the drug. And these lesions were extended to Henle´s loops by 24 hours after the administration olny in large dose group. In all renal specimens, however, arrchitecture of glomeruli and collecting ducts were relatively well preserved.
2. In the liver, rund cell infiltration in periportal connctive tissue, mild cloudy swelling of parenchymal cells, and homogenous eosinophilic substance in portal and central veins were observed 6 and 3 hous after administration in small and large dose groups, respectively.
These toxic changes such as cloudy swelling, vacuilation in the cytoplasm of hepatic cells, distortion of the hepatic cell cordis and focal necros is were aggravated in proportion to the dose administered and time elapsed.
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